Ravi

Reproductive Medicine

Learning points from regional teaching Hypothalamus-GnRH that acts on anterior pitutitary Pitutitary FSH/LH act on granulosa Ovary granulosa cells secretes inhibin3types of oestrogen :17b estradiol oestriol oestroneOestrogen helps in development of secondary sexual charecteristics and preserves bone density.Ovary’s dimension 4*1.5*1.5 cmPCOS2003 ESHRE/ASRM USS-ovarian volume >10ml2-12 mm cysts 10 or morePolygenic disorder of steroid biosynthesis or insulin metabolism.LH acts theca cell 2 cell theory SHBG reduced by androgen & insulin.SHBG produced in liver .Free androgen index =total testerone*100/SHBG. Normal